Clinical Pharmacology Practice Questions

Question 1

Which of the following statements is true regarding competitive reversible antagonism?

Accepted Answer

Efficacy and Vmax remain unchanged.

Answer

ED50 remains unchanged in competitive reversible antagonism.

Answer

Potency remains unchanged in the presence of a competitive antagonist.

Answer

Affinity (Kd) remains unchanged in competitive reversible antagonism.

Question 2

Which is the first step in carrying out an Adverse Event Following Immunization (AEFI)?

Accepted Answer

Confirm information in report

Answer

Collect data about the suspected vaccine

Answer

Observe the immunization service in action

Answer

Formulate a working hypothesis

Question 3

Volume of distribution of a drug is 500 ml and target concentration of drug in blood is 5 g/L. 20% of administered drug is reached to systemic circulation. What will be the loading dose of that drug -

Accepted Answer

12.5 gm

Answer

1 gm

Answer

5 gm

Answer

25 gm

Question 4

Which of the following statements is correct regarding the given graph?

Accepted Answer

Drug 1 represents agonist and drug 4 represents inverse agonist

Answer

Drug 1 represents agonist and drug 2 represents inverse agonist

Answer

Drug 3 represents agonist and drug 4 represents inverse agonist

Answer

Drug 2 represents partial agonist and drug 3 represents inverse agonist

Question 5

Which of the following is the most fundamental criterion that must be met by a disease before it is to be considered suitable for a screening programme?

1. The natural history of the disease should be adequately understood.
2. No effective treatment should exist for the disease.
3. The disease should not have a recognizable latent or asymptomatic stage.
4. There should be a test that can detect the disease prior to onset of signs and symptoms.

Accepted Answer

1. The natural history of the disease should be adequately understood.

Answer

4. There should be a test that can detect the disease prior to onset of signs and symptoms.

Answer

3. The disease should not have a recognizable latent or asymptomatic stage.

Answer

2. No effective treatment should exist for the disease.

Question 6

In which phase of clinical trials is drug dosing typically determined?

Accepted Answer

Phase 1

Answer

Phase 2

Answer

Phase 3

Answer

Phase 4

Answer

Phase 0

Question 7

Steps in review of patient's history during secondary survey of trauma care can be summarised as

Accepted Answer

AMPLE

Answer

TRIAGE

Answer

ABCDE

Answer

None of the options

Question 8

Diagnose the underlying medical disorder based on the ECG changes.

Accepted Answer

ECG changes due to hypocalcemia

Answer

ECG changes due to hypokalemia

Answer

ECG changes due to hypercalcemia

Answer

ECG changes due to hyperkalemia

Question 9

The drug used in steroid-refractory acute severe ulcerative colitis is:

Accepted Answer

Cyclosporine

Answer

Steroids

Answer

Infliximab

Answer

Sulfasalazine

Question 10

Modified Wells criteria is used for the initial assessment of patients with suspected pulmonary embolism.

Accepted Answer

Pulmonary embolism

Answer

Pleural Effusion

Answer

Cardiac tamponade

Answer

Myocardial infarction

Clinical Pharmacology

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Pharmacokinetics and Pharmacodynamics

Drug Metabolism and Excretion

Adverse Drug Reactions and Interactions

Therapeutic Drug Monitoring

Pharmacogenomics and Precision Medicine

Drug Development and Clinical Trials

Rational Prescribing and Deprescribing

Medication Adherence Strategies

Special Populations (Pediatric, Geriatric, Pregnancy)

Pharmacovigilance

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About Clinical Pharmacology for NEET-PG

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