A 48-year-old Caucasian male suffering from ischemic heart disease is placed on a heart transplant list. Months later, he receives a heart from a matched donor. During an endomyocardial biopsy performed 3 weeks later, there is damage consistent with acute graft rejection. What is most likely evident on the endomyocardial biopsy?
AGranuloma
BAtherosclerosis
CLymphocytic infiltrate
DTissue necrosis
EFibrosis
A 31-year-old female receives a kidney transplant for autosomal dominant polycystic kidney disease (ADPKD). Three weeks later, the patient experiences acute, T-cell mediated rejection of the allograft and is given sirolimus. Which of the following are side effects of this medication?
ANephrotoxicity, hypertension
BHyperlipidemia, thrombocytopenia
CNephrotoxicity, gingival hyperplasia
DPancreatitis
ECytokine release syndrome, hypersensitivity reaction
A 40-year-old male with a history of chronic alcoholism recently received a liver transplant. Two weeks following the transplant, the patient presents with a skin rash and frequent episodes of bloody diarrhea. A colonoscopy is performed and biopsy reveals apoptosis of colonic epithelial cells. What is most likely mediating these symptoms?
ADonor T-cells
BRecipient T-cells
CRecipient B-cells
DRecipient antibodies
EDonor B-cells
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