Opioid use disorderDownloads

A 32-year-old man is brought to the emergency department because he was found stumbling in the street heedless of oncoming traffic. On arrival, he is found to be sluggish and has slow and sometimes incoherent speech. He is also drowsy and falls asleep several times during questioning. Chart review shows that he has previously been admitted after getting a severe cut during a bar fight. Otherwise, he is known to be intermittently homeless and has poorly managed diabetes. Serum testing reveals the presence of a substance that increases the duration of opening for an important channel. Which of the following symptoms may be seen if the most likely substance in this patient is abruptly discontinued?

A 25-year-old woman comes into her family doctor’s clinic confused as to how she failed her work-required urine drug test. The patient has no significant past medical history and takes no medications. She states that she does not smoke and denies ever using any alcohol or recreational drugs. The patient’s social history reveals a recent change in her diet. For the past 2-weeks, she was experimenting with a ketogenic diet and using poppy seed bagels as her only source of carbohydrates. Her vital signs and physical examination are within normal limits. Which of the following physical exam findings might be present had this patient really been abusing the class of drug for which she most likely tested positive?