Chapter·PhysiologyGlomerular filtration

Glomerular structure and functionDownloads

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Sample Questions

1

A 55-year-old woman presents to a physician’s clinic for a diabetes follow-up. She recently lost weight and believes the diabetes is ‘winding down’ because the urinary frequency has slowed down compared to when her diabetes was "at its worst". She had been poorly compliant with medications, but she is now asking if she can decrease her medications as she feels like her diabetes is improving. Due to the decrease in urinary frequency, the physician is interested in interrogating her renal function. Which substance can be used to most accurately assess the glomerular filtration rate (GFR) in this patient?

APara-aminohippurate (PAH)

BGlucose

CInulin

DUrea

ECreatinine

2

On cardiology service rounds, your team sees a patient admitted with an acute congestive heart failure exacerbation. In congestive heart failure, decreased cardiac function leads to decreased renal perfusion, which eventually leads to excess volume retention. To test your knowledge of physiology, your attending asks you which segment of the nephron is responsible for the majority of water absorption. Which of the following is a correct pairing of the segment of the nephron that reabsorbs the majority of all filtered water with the means by which that segment absorbs water?

ADistal convoluted tubule via passive diffusion following ion reabsorption

BDistal convoluted tubule via aquaporin channels

CThick ascending loop of Henle via passive diffusion following ion reabsorption

DProximal convoluted tubule via passive diffusion following ion reabsorption

ECollecting duct via aquaporin channels

3

A 70-year-old female with chronic kidney failure secondary to diabetes asks her nephrologist to educate her about the techniques used to evaluate the degree of kidney failure progression. She learns about the concept of glomerular filtration rate (GFR) and learns that it can be estimated by measuring the levels of some substances. The clearance of which of the following substances is the most accurate estimate for GFR?

AParaaminohippurate (PAH)

BSodium

CInulin

DCreatinine

EGlucose

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