Chapter·PhysiologyGlomerular filtration

Determinants of GFRDownloads

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1

Which factor most strongly influences protein filtration at the glomerulus?

AElectrical charge

BMolecular size

CShape

DTemperature

2

A healthy 30-year-old female has a measured creatinine clearance of 100 mL/min. She has a filtration fraction (FF) of 25%. Serum analysis reveals a creatinine level of 0.9 mg/dL and an elevated hematocrit of 0.6. Which of the following is the best estimate of this patient’s renal blood flow?

A1.2 L/min

B600 mL/min

C800 mL/min

D400 mL/min

E1.0 L/min

3

On cardiology service rounds, your team sees a patient admitted with an acute congestive heart failure exacerbation. In congestive heart failure, decreased cardiac function leads to decreased renal perfusion, which eventually leads to excess volume retention. To test your knowledge of physiology, your attending asks you which segment of the nephron is responsible for the majority of water absorption. Which of the following is a correct pairing of the segment of the nephron that reabsorbs the majority of all filtered water with the means by which that segment absorbs water?

ADistal convoluted tubule via passive diffusion following ion reabsorption

BDistal convoluted tubule via aquaporin channels

CThick ascending loop of Henle via passive diffusion following ion reabsorption

DProximal convoluted tubule via passive diffusion following ion reabsorption

ECollecting duct via aquaporin channels

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