Chapter·PharmacologyAntihypertensives

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Sample Questions

1

A 68-year-old man with hypertension comes to the physician because of fatigue and difficulty initiating urination. He wakes up several times a night to urinate. He does not take any medications. His blood pressure is 166/82 mm Hg. Digital rectal examination shows a firm, non-tender, and uniformly enlarged prostate. Which of the following is the most appropriate pharmacotherapy?

AFinasteride

Bα-Methyldopa

CPhenoxybenzamine

DTerazosin

ETamsulosin

2

A 34-year-old female presents to the emergency room with headache and palpitations. She is sweating profusely and appears tremulous on exam. Vital signs are as follows: HR 120, BP 190/110, RR 18, O2 99% on room air, and Temp 37C. Urinary metanephrines and catechols are positive. Which of the following medical regimens is contraindicated as a first-line therapy in this patient?

ALabetalol

BPropranolol

CNitroprusside

DLisinopril

EPhenoxybenzamine

3

An investigator is studying a local anesthetic that causes increased sympathetic activity. When given intravenously, it causes euphoria and pupillary dilation. Which of the following is the most likely effect of this drug at the synaptic cleft?

AIncreased release of norepinephrine

BDecreased reuptake of norepinephrine

CDecreased release of acetylcholine

DIncreased release of serotonin

EDecreased breakdown of norepinephrine

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