A 25-year-old woman, gravida 2, para 1, comes to the physician for her initial prenatal visit at 18 weeks’ gestation. She is a recent immigrant from Thailand. Her history is significant for anemia since childhood that has not required any treatment. Her mother and husband have anemia, as well. She has no history of serious illness and takes no medications. Her vital signs are within normal limits. Fundal height measures at 22 weeks. Ultrasound shows polyhydramnios and pleural and peritoneal effusion in the fetus with fetal subcutaneous edema. Which of the following is the most likely clinical course for this fetus?
ANeonatal death
BNormal development with regular blood transfusion
CAsymptomatic anemia
DIntrauterine fetal demise
ECarrier state
A 38-year-old G1P0 woman presents to her obstetrician for a prenatal visit. She reports feeling well and has no acute concerns. She is currently at 28 weeks gestation previously confirmed by ultrasound. She takes her folate supplements daily. She has a 10-pack-year smoking history and currently smokes half a pack per day. On physical exam, the uterus is soft and globular. The top of the uterine fundus is found around the level of the umbilicus. A fetal ultrasound demonstrates a reduced liver volume and subcutaneous fat with relative sparing of the head. Which of the following is most likely the cause of this patient's ultrasound findings?
ACigarette smoking
BAneuploidy
CFetal congenital heart disease
DNeural tube defect
EFetal infection
A 40-year-old, gravida 2, nulliparous woman, at 14 weeks' gestation comes to the physician because of a 6-hour history of light vaginal bleeding and lower abdominal discomfort. Eight months ago she had a spontaneous abortion at 10 weeks' gestation. Her pulse is 92/min, respirations are 18/min, and blood pressure is 134/76 mm Hg. Abdominal examination shows no tenderness or masses; bowel sounds are normal. On pelvic examination, there is old blood in the vaginal vault and at the closed cervical os. The uterus is larger than expected for the length of gestation and there are bilateral adnexal masses. Serum β-hCG concentration is 120,000 mIU/ml. Which of the following is the most appropriate next step in management?
AFetal blood sampling
BFetal Doppler ultrasound
CChorionic villus sampling
DThyroid function tests
ETransvaginal ultrasound
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