A 35-year-old male anesthesiologist presents to the occupational health clinic after a needlestick exposure while obtaining an arterial line in a patient with cirrhosis. In addition to a standard bloodborne pathogen laboratory panel sent for all needlestick exposures at his hospital, additional hepatitis panels are ordered upon the patient's request. The patient's results are shown below: HIV 4th generation Ag/Ab: Negative/Negative Hepatitis B surface antigen (HBsAg): Negative Hepatitis C antibody: Negative Anti-hepatitis B surface antibody (HBsAb): Positive Anti-hepatitis B core IgM antibody (HBc IgM): Negative Anti-hepatitis B core IgG antibody (HBc IgG): Positive What is the most likely explanation of the results above?
AWindow period
BChronic infection
CAcute infection
DImmune due to infection
EImmune due to vaccination
A 60-year-old man comes to the physician’s office with jaundice. Liver ultrasound reveals a shrunken liver and biopsy reveals cirrhosis. Hepatitis serologies are below: Anti-HAV: negative HBsAg: negative HBsAb: positive HBeAg: negative Anti-HBe: negative Anti-HBc: negative Anti-HCV: positive The hepatitis C viral load is 1,000,000 copies/mL. The patient is started on an antiviral regimen including sofosbuvir. What is the mechanism of action of this drug?
AInhibits reverse transcriptase
BInhibits integrase
CInhibits synthesis of DNA-dependent DNA polymerase
DInhibits RNA-dependent RNA polymerase
EInhibits hepatitis C protease
A 52-year-old male patient with chronic alcoholism presents to an ambulatory medical clinic, where the hepatologist elects to perform comprehensive hepatitis B screening, in addition to several other screening and preventative measures. Given the following choices, which serologic marker, if positive, would indicate the patient’s immunity to the hepatitis B virus?
AHBeAb
BHBeAg
CHBsAb
DHBsAg
EHBcAb
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