An investigator is studying the chemical structure of antibiotics and its effect on bacterial growth. He has synthesized a simple beta-lactam antibiotic and has added a bulky side chain to the molecule that inhibits the access of bacterial enzymes to the beta-lactam ring. The synthesized drug will most likely be appropriate for the treatment of which of the following conditions?
AFolliculitis
BNocardiosis
CAtypical pneumonia
DErythema migrans
EOtitis media
A 24-year-old woman presents to the ED with symptoms of pelvic inflammatory disease despite being previously treated with azithromycin for chlamydial infection. Based on your clinical understanding about the epidemiology of PID, you decide to obtain a gram stain which shows a gram-negative diplococci. What is the next step in order to confirm the identity of the organism described?
APerform an RT-PCR
BCulture in TCBS agar
CCulture in Thayer-Martin media
DObtain an acid fast stain
ECulture in Bordet-Gengou agar
Three days after admission to the hospital following a motor vehicle accident, a 45-year-old woman develops a fever. A central venous catheter was placed on the day of admission for treatment of severe hypotension. Her temperature is 39.2°C (102.5°F). Examination shows erythema surrounding the catheter insertion site at the right internal jugular vein. Blood cultures show gram-positive, catalase-positive cocci that have a high minimum inhibitory concentration when exposed to novobiocin. Which of the following is the most appropriate pharmacotherapy?
AClarithromycin
BVancomycin
CMetronidazole
DPenicillin G
EPolymyxin B
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