A 52-year-old woman with type 2 diabetes mellitus comes to the physician because of a 2-day history of blisters on her forearms and pain during sexual intercourse. Her only medications are metformin and glyburide. Examination reveals multiple, flaccid blisters on the volar surface of the forearms and ulcers on the buccal, gingival, and vulvar mucosa. The epidermis on the forearm separates when the skin is lightly stroked. Which of the following is the most likely diagnosis?
ABehcet disease
BPemphigus vulgaris
CToxic epidermal necrolysis
DDermatitis herpetiformis
ELichen planus
A 52-year-old Caucasian man presents to the clinic for evaluation of a mole on his back that he finds concerning. He states that his wife noticed the lesion and believes that it has been getting larger. On inspection, the lesion is 10 mm in diameter with irregular borders. A biopsy is performed. Pathology reveals abnormal melanocytes forming nests at the dermo-epidermal junction and discohesive cell growth into the epidermis. What is the most likely diagnosis?
ADesmoplastic melanoma
BLentigo maligna melanoma
CSuperficial spreading melanoma
DNodular melanoma
EAcral lentiginous melanoma
A 4-year-old boy is presented to the clinic by his mother due to a peeling erythematous rash on his face, back, and buttocks which started this morning. Two days ago, the patient’s mother says his skin was extremely tender and within 24 hours progressed to desquamation. She also says that, for the past few weeks, he was very irritable and cried more than usual during diaper changes. The patient is up to date on his vaccinations and has been meeting all developmental milestones. No significant family history. On physical examination, the temperature is 38.4°C (101.1°F) and the pulse is 70/min. The epidermis separates from the dermis by gentle lateral stroking of the skin. Systemic antibiotics are prescribed, and adequate fluid replacement is provided. Which of the following microorganisms most likely caused this patient’s condition?
AClostridium sp.
BStaphylococcus aureus
CNeisseria meningitidis
DBacillus anthracis
EStreptococcus sp.
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