A 25-year-old man with a genetic disorder presents for genetic counseling because he is concerned about the risk that any children he has will have the same disease as himself. Specifically, since childhood he has had difficulty breathing requiring bronchodilators, inhaled corticosteroids, and chest physiotherapy. He has also had diarrhea and malabsorption requiring enzyme replacement therapy. If his wife comes from a population where 1 in 10,000 people are affected by this same disorder, which of the following best represents the likelihood a child would be affected as well?
A0.01%
B2%
C0.5%
D1%
E50%
A randomized control double-blind study is conducted on the efficacy of 2 sulfonylureas. The study concluded that medication 1 was more efficacious in lowering fasting blood glucose than medication 2 (p ≤ 0.05; 95% CI: 14 [10-21]). Which of the following is true regarding a 95% confidence interval (CI)?
AIf the same study were repeated multiple times, approximately 95% of the calculated confidence intervals would contain the true population parameter.
BThe 95% confidence interval is the probability chosen by the researcher to be the threshold of statistical significance.
CWhen a 95% CI for the estimated difference between groups contains the value ‘0’, the results are significant.
DIt represents the probability that chance would not produce the difference shown, 95% of the time.
EThe study is adequately powered at the 95% confidence interval.
You are reading through a recent article that reports significant decreases in all-cause mortality for patients with malignant melanoma following treatment with a novel biological infusion. Which of the following choices refers to the probability that a study will find a statistically significant difference when one truly does exist?
AType II error
BType I error
CConfidence interval
Dp-value
EPower
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