Calculation from absolute risk reductionDownloads

A 35-year-old woman is started on a new experimental intravenous drug X. In order to make sure that she is able to take this drug safely, the physician in charge of her care calculates the appropriate doses to give to this patient. Data on the properties of drug X from a subject with a similar body composition to the patient is provided below: Weight: 100 kg Dose provided: 1500 mg Serum concentration 15 mg/dL Bioavailability: 1 If the patient has a weight of 60 kg and the target serum concentration is 10 mg/dL, which of the following best represents the loading dose of drug X that should be given to this patient?

A researcher is designing an experiment to examine the toxicity of a new chemotherapeutic agent in mice. She splits the mice into 2 groups, one of which she exposes to daily injections of the drug for 1 week. The other group is not exposed to any intervention. Both groups are otherwise raised in the same conditions with the same diet. One month later, she sacrifices the mice to check for dilated cardiomyopathy. In total, 52 mice were exposed to the drug, and 50 were not exposed. Out of the exposed group, 13 were found to have dilated cardiomyopathy on necropsy. In the unexposed group, 1 mouse was found to have dilated cardiomyopathy. Which of the following is the relative risk of developing cardiomyopathy with this drug?