A 25-year-old man with a genetic disorder presents for genetic counseling because he is concerned about the risk that any children he has will have the same disease as himself. Specifically, since childhood he has had difficulty breathing requiring bronchodilators, inhaled corticosteroids, and chest physiotherapy. He has also had diarrhea and malabsorption requiring enzyme replacement therapy. If his wife comes from a population where 1 in 10,000 people are affected by this same disorder, which of the following best represents the likelihood a child would be affected as well?
A0.01%
B2%
C0.5%
D1%
E50%
A scientist is studying the characteristics of a newly discovered infectious disease in order to determine its features. He calculates the number of patients that develop the disease over several months and finds that on average 75 new patients become infected per month. Furthermore, he knows that the disease lasts on average 2 years before patients are either cured or die from the disease. If the population being studied consists of 7500 individuals, which of the following is the prevalence of the disease?
A0.24
B0.02
C0.12
D0.005
E0.01
The APPLE study investigators are currently preparing for a 30-year follow-up evaluation. They are curious about the number of participants who will partake in follow-up interviews. The investigators noted that of the 83 participants who participated in the APPLE study's 20-year follow-up, 62 were in the treatment group and 21 were in the control group. Given the unequal distribution of participants between groups at follow-up, this finding raises concerns for which of the following?
AVolunteer bias
BReporting bias
CInadequate sample size
DAttrition bias
ELead-time bias
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