A 20-year-old woman is brought in by police for trying to break into a museum after hours. The patient states that she is a detective on the trail of a master collusion scheme and needs the artifacts from the museum to prove her case. Her family reports that she has been acting strangely for the past week. She has been up perusing the internet all night without taking breaks. Her husband states that she has had increased sexual interest for the past week; however, he did not report this to the physician when he first noticed it. The patient is unable to offer a history as she cannot be redirected from her current theory. Her temperature is 99.0°F (37.2°C), blood pressure is 122/81 mmHg, pulse is 97/min, respirations are 17/min, and oxygen saturation is 98% on room air. Physical exam is notable only for a highly-energized patient. Laboratory studies are ordered as seen below. Urine: Color: Yellow Nitrite: Negative Bacteria: Negative Leukocytes: Negative hCG: Positive Benzodiazepines: Negative Barbiturate: Negative Cocaine: Negative Acetaminophen: Negative Which of the following is the most appropriate next step in management?
ALithium
BValproic acid
CFluoxetine
DHaloperidol
EElectroconvulsive therapy
A 35-year-old man is brought to the emergency department by his wife. She was called by his coworkers to come and pick him up from work after he barged into the company’s board meeting and was being very disruptive as he ranted on about all the great ideas he had for the company. When they tried to reason with him, he became hostile and insisted that he should be the CEO as he knew what was best for the future of the company. The patient’s wife also noted that her husband has been up all night for the past few days but assumed that he was handling a big project at work. The patient has no significant past medical or psychiatric history. Which of the following treatments is most likely to benefit this patient’s condition?
AAntidepressants
BValproic acid
CHaloperidol
DPsychotherapy
EClozapine
A 22-year-old woman is brought to the emergency department 20 minutes after being detained by campus police for attempting to steal from the bookstore. Her roommate says that the patient has been acting strangely over the last 2 weeks. She has not slept in 4 days and has painted her room twice in that time span. She has also spent all of her savings on online shopping and lottery tickets. She has no history of psychiatric illness or substance abuse, and takes no medications. During the examination, she is uncooperative, combative, and refusing care. She screams, “Let me go, God has a plan for me and I must go finish it!”. Her temperature is 37.2°C (99°F), pulse is 75/min, respirations are 16/min, and blood pressure is 130/80 mm Hg. Physical examination shows no abnormalities. On mental status examination, she describes her mood as “amazing.” She has a labile affect, speaks rapidly, and her thought process is tangential. She denies having any hallucinations. Which of the following is the most appropriate initial pharmacotherapy?
AClozapine
BSertraline
CLithium
DValproate
EHaloperidol
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