Chapter·PsychiatryAnxiety

Pharmacotherapy for anxiety disordersDownloads

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1

A 42-year-old man comes to the emergency department complaining of chest pain. He states that he was at the grocery store when he developed severe, burning chest pain along with palpitations and nausea. He screamed for someone to call an ambulance. He says this has happened before, including at least 4 episodes in the past month that were all in different locations including once at home. He is worried that it could happen at work and affect his employment status. He has no significant past medical history, and reports that he does not like taking medications. He has had trouble in the past with compliance due to side effects. The patient’s temperature is 98.9°F (37.2°C), blood pressure is 133/74 mmHg, pulse is 110/min, and respirations are 20/min with an oxygen saturation of 99% on room air. On physical examination, the patient is tremulous and diaphoretic. He continually asks to be put on oxygen and something for his pain. An electrocardiogram is obtained that shows tachycardia. Initial troponin level is negative. A urine drug screen is negative. Thyroid stimulating hormone and free T4 levels are normal. Which of the following is first line therapy for the patient for long-term management?

ACognitive behavioral therapy

BAlprazolam

CImipramine

DFluoxetine

EBuspirone

2

A 27-year-old woman presents to the psychiatrist due to feelings of sadness for the past 3 weeks. She was let go from her job 1 month ago, and she feels as though her whole life is coming to an end. She is unable to sleep well at night and also finds herself crying at times during the day. She has not been able to eat well and has been losing weight as a result. She has no will to go out and meet with her friends, who have been extremely supportive during this time. Her doctor gives her an antidepressant which blocks the reuptake of both serotonin and norepinephrine to help with these symptoms. One week later, she is brought to the emergency room by her friends who say that she was found to be in a state of euphoria. They mention bizarre behavior, one of which is booking a plane ticket to New York, even though she has 3 interviews lined up the same week. Her words cannot be understood as she is speaking very fast, and she is unable to sit in one place for the examination. Which of the following was most likely prescribed by her psychiatrist?

ABupropion

BVenlafaxine

CSertraline

DFluvoxamine

ELithium

3

An 8-year-old boy is brought to the emergency department by his parents 30 minutes after losing consciousness. He was at a water park with his family when he fell to the ground and started to have jerking movements of the arms and legs. On arrival, he continues to have generalized, violent muscle contractions and is unresponsive to verbal and painful stimuli. The emergency department physician administers lorazepam. The expected beneficial effect of this drug is most likely caused by which of the following mechanisms?

AIncreased affinity of GABAA receptors for GABAB agonists

BNoncompetitive NMDA receptor antagonism

CIncreased duration of chloride channel opening

DAllosteric activation of GABAA receptors

EInhibition of GABA transaminase

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