A 28-year-old woman presents to her primary care physician complaining of intense thirst and frequent urination for the past 2 weeks. She says that she constantly feels the urge to drink water and is also going to the bathroom to urinate frequently throughout the day and multiple times at night. She was most recently hospitalized 1 month prior to presentation following a motor vehicle accident in which she suffered severe impact to her head. The physician obtains laboratory tests, with the results shown below: Serum: Na+: 149 mEq/L Cl-: 103 mEq/L K+: 3.5 mEq/L HCO3-: 24 mEq/L BUN: 20 mg/dL Glucose: 105 mg/dL Urine Osm: 250 mOsm/kg The patient’s condition is most likely caused by inadequate hormone secretion from which of the following locations?
AAdrenal cortex
BAnterior pituitary
CPreoptic nucleus of the hypothalamus
DSuprachiasmatic nucleus of the hypothalamus
EPosterior pituitary
A 56-year-old man is seen in the hospital for a chief complaint of intense thirst and polyuria. His history is significant for recent transsphenoidal resection of a pituitary adenoma. With regard to the man's fluid balance, which of the following would be expected?
AHyponatremia
BIncreased extracellular fluid osmolarity
CSerum osmolarity <290 mOsm/L
DElevated serum ADH
EElevated blood glucose
A 66-year-old man with congestive heart failure presents to the emergency department complaining of worsening shortness of breath. These symptoms have worsened over the last 3 days. He has a blood pressure of 126/85 mm Hg and heart rate of 82/min. Physical examination is notable for bibasilar crackles. A chest X-ray reveals bilateral pulmonary edema. His current medications include metoprolol succinate and captopril. You wish to add an additional medication targeted towards his symptoms. Of the following, which statement is correct regarding loop diuretics?
ALoop diuretics can cause metabolic acidosis
BLoop diuretics can cause ammonia toxicity
CLoop diuretics can cause hyperlipidemia
DLoop diuretics decrease sodium, magnesium, and chloride but increase calcium
ELoop diuretics inhibit the action of the Na+/K+/Cl- cotransporter
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