Which factor most strongly influences protein filtration at the glomerulus?
AElectrical charge
BMolecular size
CShape
DTemperature
A healthy 30-year-old female has a measured creatinine clearance of 100 mL/min. She has a filtration fraction (FF) of 25%. Serum analysis reveals a creatinine level of 0.9 mg/dL and an elevated hematocrit of 0.6. Which of the following is the best estimate of this patient’s renal blood flow?
A1.2 L/min
B600 mL/min
C800 mL/min
D400 mL/min
E1.0 L/min
An investigator is studying the effect of antihypertensive drugs on cardiac output and renal blood flow. For comparison, a healthy volunteer is given a placebo and a continuous infusion of para-aminohippuric acid (PAH) to achieve a plasma concentration of 0.02 mg/ml. His urinary flow rate is 1.5 ml/min and the urinary concentration of PAH is measured to be 8 mg/ml. His hematocrit is 50%. Which of the following values best estimates cardiac output in this volunteer?
A8 L/min
B3 L/min
C4 L/min
D1.2 L/min
E6 L/min
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