A patient with Graves' disease is treated with thiocyanate (a historical antithyroid agent). Thiocyanate helps reduce thyroid hormone production by:
AInhibiting thyroid peroxidase
BInhibiting 5'-deiodinase
CInhibiting iodide follicular uptake
DInhibiting beta-adrenergic receptors
EInhibiting thyroid deiodinase
A 49-year-old woman presents to the office because of tremors for 2 months. She says that her hands have been shaking a lot, especially when she feels stressed. In addition, she has been sweating more than usual and has lost 8 kg (17.6 lb) in the last 2 months. She has a past medical history of vitiligo. Her vital signs are a heart rate of 98/min, a respiratory rate of 14/min, a temperature of 37.6°C (99.7°F), and a blood pressure of 115/75 mm Hg. Physical examination shows a fine, bilateral hand tremor and a diffuse goiter. Which of the following hormonal imbalances is most likely present?
ALow TSH, high free T4, and high free T3
BHigh TSH, high free T4, and high free T3
CHigh TSH, normal free T4, and normal free T3
DLow TSH, normal free T4, and normal free T3
EHigh TSH, low free T4, and low free T3
A 31-year-old woman presents to her primary care physician with a 2-week history of diarrhea. She says that she has also noticed that she is losing weight, which makes her feel anxious since she has relatives who have suffered from anorexia. Finally, she says that she is worried she has a fever because she feels warm and has been sweating profusely. On physical examination she is found to have proptosis, fine tremor of her hands, and symmetrical, non-tender thyroid enlargement. Which of the following types of enzymes is targeted by a treatment for this disease?
APeroxidase
BKinase
CCatalase
DCyclooxygenase
EPhosphatase
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