Which factor most strongly influences protein filtration at the glomerulus?
AElectrical charge
BMolecular size
CShape
DTemperature
A 56-year-old man with coronary artery disease agrees to participate in a pharmacological study. He takes an oral medication that leads to dephosphorylation of myosin light chains in venous smooth muscle cells. An investigator measures the plasma concentration of the drug over time after intravenous and then after oral administration. There is no statistically significant difference in the dose-corrected area under the curve for the 2 routes of administration. The patient most likely ingested which of the following drugs?
AIsosorbide mononitrate
BNitroglycerine
CNimodipine
DNifedipine
ENitroprusside
A 5-year-old boy undergoes MRI neuroimaging for the evaluation of worsening headaches and intermittent nausea upon awakening. He receives a bolus of intravenous thiopental for sedation during the procedure. Ten minutes after the MRI, the patient is awake and responsive. Which of the following pharmacological properties is most likely responsible for this patient's rapid recovery from this anesthetic agent?
AFirst-pass metabolism
BRedistribution
CZero-order elimination
DIon trapping
ECytochrome P450 oxidation
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