A 36-year-old woman comes to the emergency department because of an itchy lesion on her skin. The rash developed shortly after she took an antibiotic for a urinary tract infection. Her temperature is 37.5°C (99.3°F), pulse is 99/min, and blood pressure is 100/66 mm Hg. Physical examination shows swelling of the face and raised, erythematous plaques on her trunk and extremities. Which of the following is the most likely cause of this patient's current condition?
ADeficiency of C1 inhibitor
BSecretion of cytokines by T cells
CDeposition of immune complexes
DRelease of a vasoactive amine
EActivation of complement cascade
A 15-year-old boy is admitted to the emergency department with neck stiffness, maculopapular rash, fever, and a persistent headache. A blood culture shows encapsulated gram-negative diplococci. He has had this same infection before. Which of the following proteins is likely to be deficient in this patient?
AC9
BC1 esterase inhibitor
CCD55 (decay accelerating factor)
DCalcineurin
ECD4
A 25-year-old woman is being evaluated due to complaint of fatigue and voiding pink urine. The laboratory results are as follows: Hb 6.7 Red blood cell count 3.0 x 1012/L Leukocyte count 5,000/mm3 Platelets 170 x 109/L Reticulocyte count 6% Hematocrit 32% The physician thinks that the patient is suffering from an acquired mutation in hematopoietic stem cells, which is confirmed by flow cytometry analysis that revealed these cells are CD 55 and CD 59 negative. However, the physician is interested in knowing the corrected reticulocyte count before starting the patient on eculizumab. What value does the physician find after calculating the corrected reticulocyte count?
A3.1%
B0.4%
C0.1%
D0.6%
E4.6%
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