Chapter·PharmacologyDrug interactions and adverse effects

P-glycoprotein interactionsDownloads

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1

An investigator is comparing the risk of adverse effects among various antiarrhythmic medications. One of the drugs being studied primarily acts by blocking the outward flow of K+ during myocyte repolarization. Further investigation shows that the use of this drug is associated with a lower rate of ventricular tachycardia, ventricular fibrillation, and torsades de pointes when compared to similar drugs. Which of the following drugs is most likely being studied?

AVerapamil

BProcainamide

CEsmolol

DAmiodarone

ESotalol

2

Which transport mechanism is primarily responsible for calcium reabsorption in the proximal tubule?

AParacellular transport

BFacilitated diffusion

CActive transport

DAntiport with sodium

3

A 63-year-old man with a history of hypertension and atrial fibrillation is brought into the emergency room and found to have a ventricular tachyarrhythmia. Ibutilide is discontinued and the patient is switched to another drug that also prolongs the QT interval but is associated with a decreased risk of torsades de pointes. Which drug was most likely administered in this patient?

AEsmolol

BDigoxin

CSotalol

DAmiodarone

EQuinidine

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