A 56-year-old postmenopausal woman comes to the physician because of a 6-month history of worsening pain and swelling in her left knee. She has a history of peptic ulcer disease for which she takes cimetidine. Examination shows palpable crepitus and limited range of motion of the left knee. Which of the following is the most appropriate pharmacotherapy for this patient’s symptoms?
AAcetylsalicylic acid
BDiclofenac
CMeloxicam
DCelecoxib
EKetorolac
A 17-year-old girl is brought to the emergency department 6 hours after she attempted suicide by consuming 16 tablets of acetaminophen (500 mg per tablet). At present, she does not have any complaints or symptoms. The patient is afebrile and vital signs are within normal limits. Physical examination is unremarkable. Laboratory findings show a serum acetaminophen level that is predictive of ‘probable hepatic toxicity’ on the Rumack-Matthew nomogram. Treatment is started with a drug, which is a precursor of glutathione and is a specific antidote for acetaminophen poisoning. Which of the following is an additional beneficial mechanism of action of this drug in this patient?
APromotes glucuronidation of unmetabolized acetaminophen
BPromotes microcirculatory blood flow
CPromotes fecal excretion of unabsorbed acetaminophen
DPrevents gastrointestinal absorption of acetaminophen
EPromotes oxidation of N-acetyl-p-benzoquinoneimine (NAPQI)
A 14-year-old boy is brought to the emergency department because of a 4-hour history of vomiting, lethargy, and confusion. Three days ago, he was treated with an over-the-counter medication for fever and runny nose. He is oriented only to person. His blood pressure is 100/70 mm Hg. Examination shows bilateral optic disc swelling and hepatomegaly. His blood glucose concentration is 65 mg/dL. Toxicology screening for serum acetaminophen is negative. The over-the-counter medication that was most likely used by this patient has which of the following additional effects?
AIncreased partial thromboplastin time
BDecreased uric acid elimination
CDecreased expression of glycoprotein IIb/IIIa
DIrreversible inhibition of ATP synthase
EIrreversible inhibition of cyclooxygenase-1
+ 7 more in the PDF
Browse all chapters