Chapter·PharmacologyCNS drugs (antiepileptics, anesthetics)

Local anestheticsDownloads

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1

During a nerve conduction study, which of the following ions is primarily responsible for the rapid upstroke of the action potential?

ACalcium

BSodium

CChloride

DPotassium

2

Two hours after undergoing elective cholecystectomy with general anesthesia, a 41-year-old woman is evaluated for decreased mental status. BMI is 36.6 kg/m2. Respirations are 18/min and blood pressure is 126/73 mm Hg. Physical examination shows the endotracheal tube in normal position. She does not respond to sternal rub and gag reflex is absent. Arterial blood gas analysis on room air shows normal PO2 and PCO2 levels. Which of the following anesthetic properties is the most likely cause of these findings?

ALow blood solubility

BHigh lipid solubility

CLow brain-blood partition coefficient

DHigh minimal alveolar concentration

ELow cytochrome P450 activity

3

A group of researchers is studying various inhaled substances to determine their anesthetic properties. In particular, they are trying to identify an anesthetic with fast onset and quick recovery for use in emergencies. They determine the following data: Inhalational anesthetic Blood-gas partition coefficient A 0.15 B 0.92 C 5.42 Which of the following statements is accurate with regard to these inhaled anesthetic substances?

AAgent C has the fastest onset of action

BAgent A has the fastest onset of action

CAgent B is the most potent

DAgent B has the fastest onset of action

EAgent A is the most potent

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