A 23-year-old woman presents to the emergency department with acute onset of shortness of breath, wheezing, and chest tightness. This is her 4th visit for these symptoms in the last 5 years. She tells you she recently ran out of her normal "controller" medication. Concerned for an asthma exacerbation, you begin therapy with a short-acting beta2-agonist. What is the expected cellular response to your therapy?
AGs protein coupled receptor activates adenylyl cyclase and increases intracellular cAMP
BGq protein coupled receptor activates phospholipase C and increases intracellular calcium
CGq protein coupled receptor activates adenylyl cyclase and increases intracellular cAMP
DGs protein coupled receptor activates phospholipase C and increases intracellular calcium
EGi protein coupled receptor inhibits adenylyl cyclase and decreases cAMP
A patient presents with periods of severe headaches and flushing however every time they have come to the physician they have not experienced any symptoms. The only abnormal finding is a blood pressure of 175 mmHg/100 mmHg. It is determined that the optimal treatment for this patient is surgical. Prior to surgery which of the following noncompetitive inhibitors should be administered?
APhentolamine
BIsoproterenol
CAtropine
DPropranolol
EPhenoxybenzamine
A 45-year-old unconscious man is brought to the emergency department by a friend who witnessed him collapse. They were working in a greenhouse spraying the vegetables when the man started to complain of blurred vision and nausea. On the way to the hospital, the man lost consciousness and lost bladder continence. The patient’s vital signs are as follows: blood pressure 95/60 mm Hg; heart rate 59/min; respiratory rate 22/min; and temperature 36.0℃ (96.8℉). On examination, he is unconscious with a GCS score of 7. His pupils are contracted and react poorly to light. Lung auscultation reveals diffuse wheezing. Cardiac auscultation is significant for bradycardia. Abdominal auscultation reveals increased bowel sounds. A cardiac monitor shows bradycardia with grade 2 AV-block. Which of the following leads to the cardiac manifestations seen in this patient?
AActivation of M1-cholinergic receptors
BActivation of β2-adrenergic receptors
CActivation of M2-cholinergic receptors
DInhibition of β1-adrenergic receptors
EInhibition of M2-cholinergic receptors
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