Chapter·PharmacologyAntimicrobials

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1

A 40-year-old woman presents to clinic with multiple complaints. She complains of swelling around her eyes (Image A) and generalized weakness. A complete blood count reveals eosinophilia. She recently returned from a trip to Asia where she reports having eaten street food, including pork. If this patient's disease is explained by a parasite that causes inflammation of skeletal muscle, what would be the appropriate treatment?

APraziquantel

BNiridazole

CAlbendazole or mebendazole

DIvermectin

EDiethylcarbamazine

2

A 68-year-old man presents to his physician for symptoms of chronic weight loss, abdominal bloating, and loose stools. He notes that he has also been bothered by a chronic cough. The patient’s laboratory work-up includes a WBC differential, which is remarkable for an eosinophil count of 9%. Stool samples are obtained, with ova and parasite examination revealing roundworm larvae in the stool and no eggs. Which of the following parasitic worms is the cause of this patient’s condition?

ATaenia saginata

BTaenia solium

CStrongyloides stercoralis

DNecator americanus

EAscaris lumbricoides

3

A 31-year-old man comes to the physician because of several months of recurrent abdominal pain and diarrhea. Six months ago, he traveled to Lake Superior for a fishing trip with his friends, during which they often ate their day's catch for dinner. Physical examination shows pallor. Laboratory studies show macrocytic anemia with eosinophilia. A peripheral blood smear shows megaloblasts and hypersegmented neutrophils. A cestode infection is suspected and a drug is prescribed that kills cestodes by inducing uncontrollable muscle spasm in the parasite. The drug prescribed for this patient most likely acts by which of the following mechanisms of action?

AIncreased calcium influx into the sarcoplasm

BIncreased potassium efflux from the sarcoplasm

CIncreased sodium efflux from the sarcoplasm

DPhosphorylation of adenosine diphosphate

EBlockade of myosin binding sites

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