A 45-year-old HIV-positive male presents to his primary care physician complaining of decreased libido. He reports that he has been unable to maintain an erection for the past two weeks. He has never encountered this problem before. He was hospitalized four weeks ago for cryptococcal meningitis and has been on long-term antifungal therapy since then. His CD4 count is 400 cells/mm^3 and viral load is 5,000 copies/ml. He was previously non-compliant with HAART but since his recent infection, he has been more consistent with its use. His past medical history is also notable for hypertension, major depressive disorder, and alcohol abuse. He takes lisinopril and sertraline. His temperature is 98.6°F (37°C), blood pressure is 120/85 mmHg, pulse is 80/min, and respirations are 18/min. The physician advises the patient that side effects like decreased libido may manifest due to a drug with which of the following mechanisms of action?
AInhibition of beta-glucan synthesis
BFormation of pores in cell membrane
CInhibition of ergosterol synthesis
DDisruption of microtubule formation
EInhibition of pyrimidine synthesis
A 62-year-old man presents with dry and brittle toenails. On physical examination, his toenails are shown in the image. Which of the following is an adverse effect of the recommended treatment for this patient’s most likely condition?
AChronic renal failure
BChronic depression
CPancytopenia
DHepatitis
EHypothyroidism
A 45-year-old man comes to the physician because of a 3-day history of pain in his mouth and throat and difficulty swallowing. He has a history of COPD, for which he takes theophylline and inhaled budesonide-formoterol. Physical examination shows white patches on the tongue and buccal mucosa that can be scraped off easily. Appropriate pharmacotherapy is initiated. One week later, he returns because of nausea, palpitations, and anxiety. His pulse is 110/min and regular. Physical examination shows a tremor in both hands. Which of the following drugs was most likely prescribed?
AAmphotericin B
BGriseofulvin
CTerbinafine
DFluconazole
ENystatin
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