Chapter·PharmacologyAntibiotics

Oxazolidinones and streptograminsDownloads

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Sample Questions

1

Part of the success of the Streptococcus pyogenes bacterium lies in its ability to evade phagocytosis. Which of the following helps in this evasion?

AStreptolysin S

BStreptolysin O

CStreptokinase

DM protein

EPyrogenic toxin

2

An 18-year old college freshman presents to his university clinic because he has not been feeling well for the past two weeks. He has had a persistent headache, occasional cough, and chills without rigors. The patient’s vital signs are normal and physical exam is unremarkable. His radiograph shows patchy interstitial lung infiltrates and he is diagnosed with atypical pneumonia. The patient is prescribed azithromycin and takes his medication as instructed. Despite adherence to his drug regimen, he returns to the clinic one week later because his symptoms have not improved. The organism responsible for this infection is likely resistant to azithromycin through which mechanism?

AMutation in topoisomerase II

BMethylation of ribosomal binding site

CPresence of a beta-lactamase

DDecreased binding to RNA polymerase

EInsertion of drug efflux pumps

3

A 51-year-old man with alcohol use disorder comes to the physician because of a fever and productive cough. An x-ray of the chest shows a right lower lobe consolidation and a diagnosis of aspiration pneumonia is made. The physician prescribes a drug that blocks peptide transfer by binding to the 50S ribosomal subunit. Which of the following drugs was most likely prescribed?

ACeftriaxone

BDoxycycline

CMetronidazole

DClindamycin

EAzithromycin

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