Researchers are studying the effects of a new medication for the treatment of type 2 diabetes. A randomized group of 100 subjects is given the new medication 1st for 2 months, followed by a washout period of 2 weeks, and then administration of the gold standard medication for 2 months. Another randomized group of 100 subjects is given the gold standard medication 1st for 2 months, followed by a washout period of 2 weeks, and then administration of the new medication for 2 months. What is the main disadvantage of this study design?
AHawthorne effect
BIncreasing selection bias
CIncreasing confounding bias
DDecreasing power
ECarryover effect
A 68-year-old man comes to the physician for a follow-up examination, accompanied by his daughter. Two years ago, he was diagnosed with localized prostate cancer, for which he underwent radiation therapy. He moved to the area 1 month ago to be closer to his daughter but continues to live independently. He was recently diagnosed with osteoblastic metastases to the spine and is scheduled to initiate therapy next week. In private, the patient’s daughter says that he has been losing weight and wetting the bed, and she tearfully asks the physician if his prostate cancer has returned. She says that her father has not spoken with her about his health recently. The patient has previously expressed to the physician that he does not want his family members to know about his condition because they “would worry too much.” Which of the following initial statements by the physician is most appropriate?
A“As your father's physician, I think that it's important that you know that his prostate cancer has returned. However, we are confident that he will respond well to treatment.”
B“I'm sorry, I can't discuss any information with you without his permission. I recommend that you have an open discussion with your father.”
C“It concerns me that he's not speaking openly with you. I recommend that you seek medical power of attorney for your father. Then, we can legally discuss his diagnosis and treatment options together.”
D“It’s difficult to deal with parents aging, but I have experience helping families cope. We should sit down with your father and discuss this situation together.”
E“Your father is very ill and may not want you to know the details. I can imagine it's frustrating for you, but you have to respect his discretion.”
A 45-year-old man is brought to the emergency department by his friends because of a 1-hour history of shortness of breath and squeezing chest pain. They were at a party where cocaine was consumed. A diagnosis of acute myocardial infarction is made. The physician stabilizes the patient and transfers him to the inpatient unit. Six hours later, his wife arrives at the emergency department and requests information about her husband's condition. Which of the following is the most appropriate action by the physician?
AAsk the wife for a marriage certificate
BInform the wife about her husband's condition
CConsult the hospital ethics committee
DObtain authorization from the patient to release information
ERequest the patient's durable power of attorney document
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