A 57-year-old man comes to the physician with a 3-month history of right flank pain. Urinalysis shows 60 RBC/hpf. Renal ultrasound shows a 3 cm, well-defined mass in the upper pole of the right kidney. A photomicrograph of a section of the resected mass is shown. Which of the following is the most likely diagnosis?
AChromophobe renal cell carcinoma
BNephroblastoma
CAngiomyolipoma
DOncocytoma
EClear cell renal carcinoma
A 69-year-old man comes to the physician because of a 1-week history of blood in the urine and fatigue. He also has had a 5.0-kg (11-lb) weight loss during the past month. Physical examination shows pallor and cachexia. A nontender right flank mass is palpated. A CT scan of the chest, abdomen, and pelvis shows a 5-cm right upper pole renal mass and several pulmonary lesions. A biopsy specimen of an affected area of the lung is obtained. A photomicrograph of the biopsy specimen is shown. Molecular evaluation of the specimen is most likely to show which of the following genetic changes?
ANF1 gene inactivation
BTSC1 gene insertion
CWT1 gene deletion
DPKD1 gene mutation
EVHL gene deletion
A 4-year-old girl is being followed by the pediatric oncology team after her pediatrician found a palpable abdominal mass towards the right flank 2 weeks ago. Abdominal ultrasonography detected a solid mass in the right kidney without infiltration of the renal vein and inferior vena cava. The contrast-enhanced computed tomography (CT) confirmed the presence of a solitary mass in the right kidney surrounded by a pseudocapsule consisting of a rim of normal tissue, displacing it medially, and distorting the collecting system. No nodal involvement was detected. In which of the following chromosomes would you expect a genetic abnormality?
AChromosome 13
BChromosome 1
CChromosome 3
DChromosome 22
EChromosome 11
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