Chapter·PathologyRenal pathology

Pyelonephritis and urinary tract infectionsDownloads

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1

A 62-year-old man comes to the physician because of a 2-day history of fever, chills, and flank pain. Five days ago, he was catheterized for acute urinary retention. His temperature is 39.3°C (102.7°F). Physical examination shows right-sided costovertebral angle tenderness. Urine studies show numerous bacteria and WBC casts. Urine culture on blood agar grows mucoid, gray-white colonies. Urine culture on eosin methylene blue agar grows purple colonies with no metallic green sheen. Which of the following is the most likely causal pathogen?

AEscherichia coli

BKlebsiella pneumoniae

CPseudomonas aeruginosa

DProteus mirabilis

EStaphylococcus saprophyticus

2

A 28-year-old woman comes to the physician because of a 4-day history of lower abdominal pain and pain with urination. Five months ago, she was treated for gonococcal urethritis. She recently moved in with her newlywed husband. She is sexually active with her husband and they do not use condoms. Her only medication is an oral contraceptive. Her temperature is 37.5°C (99.7°F) and blood pressure is 120/74 mm Hg. There is tenderness to palpation over the pelvic region. Pelvic examination shows a normal-appearing vulva and vagina. Laboratory studies show: Leukocyte count 8,400/mm3 Urine pH 6.7 Protein trace WBC 60/hpf Nitrites positive Bacteria positive Which of the following is the most likely causal organism?

AEnterococcus faecalis

BKlebsiella pneumoniae

CNeisseria gonorrhoeae

DEscherichia coli

EStaphylococcus saprophyticus

3

A 62-year-old man comes to the physician because of an oozing skin ulceration on his foot for 1 week. He has a history of type 2 diabetes mellitus and does not adhere to his medication regimen. Physical exam shows purulent discharge from an ulcer on the dorsum of his left foot. Pinprick sensation is decreased bilaterally to the level of the mid-tibia. A culture of the wound grows beta-hemolytic, coagulase-positive cocci in clusters. The causal organism most likely produces which of the following virulence factors?

AExotoxin A

BM protein

CP fimbriae

DIgA protease

EProtein A

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