Congenital renal anomaliesDownloads

A newborn infant is resuscitated and transferred to the neonatal intensive care unit. The infant has notable limb deformities as well as low-set ears and a flattened nose. He was born at 34 weeks gestation to a healthy mother who received regular obstetric follow-up. Resuscitation was notable for difficulty maintaining oxygenation in the newborn. Despite appropriate interventions, the infant is still struggling to maintain adequate oxygenation. Which of the following is most likely the cause of this patient's symptoms?

A 41-year-old man presents to the emergency department because of brownish discoloration of his urine for the last several days. The review of symptoms includes complaints of increasing abdominal girth, early satiety, and difficulty breathing on exertion. The past medical history includes essential hypertension for 19 years. The medication list includes lisinopril and hydrochlorothiazide. He had a right inguinal hernia repair when he was a teenager. He smokes 20–30 cigarettes daily for the last 21 years, and drinks alcohol socially. His father died of a hemorrhagic stroke at the age of 69 years. The vital signs include: temperature 37.0°C (98.6°F), blood pressure 131/88 mm Hg, and pulse 82/min. The physical examination is positive for a palpable right upper quadrant mass. The abdominal ultrasound shows multiple bilateral kidney cysts and hepatic cysts. Which of the following is the most likely diagnosis?