Paraneoplastic syndromesDownloads

A 74-year-old man presents to the physician with a painful lesion over his right lower limb which began 2 days ago. He says that the lesion began with pain and severe tenderness in the area. The next day, the size of the lesion increased and it became erythematous. He also mentions that a similar lesion had appeared over his left lower limb 3 weeks earlier, but it disappeared after a few days of taking over the counter analgesics. There is no history of trauma, and the man does not have any known medical conditions. On physical examination, the physician notes a cordlike tender area with erythema and edema. There are no signs suggestive of deep vein thrombosis or varicose veins. Which of the following malignancies is most commonly associated with the lesion described in the patient?

A 61-year-old man presents to the urgent care clinic complaining of cough and unintentional weight loss over the past 3 months. He works as a computer engineer, and he informs you that he has been having to meet several deadlines recently and has been under significant stress. His medical history is significant for gout, hypertension, hypercholesterolemia, diabetes mellitus type 2, and pulmonary histoplasmosis 10 years ago. He currently smokes 2 packs of cigarettes/day, drinks a 6-pack of beer/day, and he endorses a past history of cocaine use back in the early 2000s but currently denies any drug use. The vital signs include: temperature 36.7°C (98.0°F), blood pressure 126/74 mm Hg, heart rate 87/min, and respiratory rate 18/min. His physical examination shows minimal bibasilar rales, but otherwise clear lungs on auscultation, grade 2/6 holosystolic murmur, and a benign abdominal physical examination. However, on routine lab testing, you notice that his sodium is 127 mEq/L. His chest X-ray is shown in the picture. Which of the following is the most likely underlying diagnosis?