Myeloperoxidase (MPO) is a heme-containing molecule that is found in the azurophilic granules of neutrophils. Upon release, the enzyme catalyzes hypochlorous acid production during the phagocytic response. In the setting of pneumonia, which of the following clinical findings is most directly associated with myeloperoxidase activity?
AShortness of breath
BGreen color of sputum
CRust-tinged sputum
DCough
EFever
A 27-year-old male presents to his primary care physician complaining of pain with urination and eye redness. He reports that he developed these symptoms approximately one week ago. He also has noticed left knee and right heel pain that started a few days ago. He denies any recent trauma. He had an episode of abdominal pain and diarrhea ten days ago that resolved. He has otherwise felt well. On exam, he walks with a limp and his conjunctivae are erythematous. Laboratory findings are notable for an elevated erythrocyte sedimentation rate (ESR) and elevated C-reactive protein (CRP). Which of the following is most likely associated with this patient’s condition?
AAnti-centromere antibody
BHLA-B27 haplotype
CAnti-cyclic citrullinated peptide (anti-CCP) antibody
DHLA-DR4 haplotype
ERheumatoid factor
A medical examiner was called to investigate the death of a 75-year-old type 1 diabetic Caucasian male who was a retired physician. His caretaker discovered his body in the bedroom with an empty syringe and a small bottle of lispro lying on the nightstand. She explains that his wife of 50 years passed away six months ago and that he had no children or family. He had become extremely depressed and did not want to live anymore. Which of the following would be most consistent with his blood chemistry if a blood sample were taken?
AGlucose: 95 mg/dL, high insulin and C-peptide levels
BGlucose: 25 mg/dL, high insulin and absent C-peptide levels
CGlucose: 95 mg/dL, low insulin and low C-peptide levels
DGlucose: 25 mg/dL, high insulin and high C-peptide levels
EGlucose: 25 mg/dL, high insulin and normal C-peptide levels
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