Hodgkin lymphomaDownloads

A 58-year-old man presents with a lump on his neck. He says the mass gradually onset 2 months ago and has been progressively enlarging. He denies any pain, weight loss, fevers, chills, or night sweats. Past medical history is significant for HIV, diagnosed 5 years ago, managed on a new HAART regimen he just started. The patient is afebrile and vital signs are within normal limits. Physical examination shows a 3 cm mobile firm mass on the left lateral side of the neck immediately below the level of the thyroid cartilage. A biopsy of the mass is performed and reveals atypical mononuclear cells in a background of eosinophils, plasma cells, histiocytes, atypical T-lymphocytes, and binucleated Reed-Sternberg cells (shown in image). Which of the following is the most likely diagnosis in this patient?

A 35-year-old man presents with a mass on the central part of his neck. He reports it has been growing steadily for the past 2 weeks, and he has also been experiencing fatigue and recurrent fevers. No significant past medical history. The patient denies any smoking history, or alcohol or recreational drug use. He denies any recent travel in the previous 6 months. On physical examination, there are multiple enlarged submandibular and cervical lymph nodes that are firm, mobile, and non-tender. A biopsy of one of the lymph nodes is performed and shows predominantly lymphocytes and histiocytes present in a pattern ‘resembling popcorn’. A flow cytometry analysis demonstrates cells that are CD19 and CD20 positive and CD15 and CD30 negative. Which of the following is the most likely diagnosis in this patient?