Endocrine effects of non-endocrine tumorsDownloads

A 61-year-old man presents to the urgent care clinic complaining of cough and unintentional weight loss over the past 3 months. He works as a computer engineer, and he informs you that he has been having to meet several deadlines recently and has been under significant stress. His medical history is significant for gout, hypertension, hypercholesterolemia, diabetes mellitus type 2, and pulmonary histoplasmosis 10 years ago. He currently smokes 2 packs of cigarettes/day, drinks a 6-pack of beer/day, and he endorses a past history of cocaine use back in the early 2000s but currently denies any drug use. The vital signs include: temperature 36.7°C (98.0°F), blood pressure 126/74 mm Hg, heart rate 87/min, and respiratory rate 18/min. His physical examination shows minimal bibasilar rales, but otherwise clear lungs on auscultation, grade 2/6 holosystolic murmur, and a benign abdominal physical examination. However, on routine lab testing, you notice that his sodium is 127 mEq/L. His chest X-ray is shown in the picture. Which of the following is the most likely underlying diagnosis?

A 54-year-old man comes to the emergency department because of abdominal distension for the past 3 weeks. He also complains of generalized abdominal discomfort associated with nausea and decreased appetite. He was discharged from the hospital 3 months ago after an inguinal hernia repair with no reported complications. He has a history of type 2 diabetes mellitus, congestive heart failure, and untreated hepatitis C. His current medications include aspirin, atorvastatin, metoprolol, lisinopril, and metformin. His father has a history of alcoholic liver disease. He has smoked one pack of cigarettes daily for 30 years but quit 5 years ago. He drinks 3–4 beers daily. He appears cachectic. His vital signs are within normal limits. Examination shows a distended abdomen and shifting dullness. There is no abdominal tenderness or palpable masses. There is a well-healed surgical scar in the right lower quadrant. Examination of the heart and lung shows no abnormalities. He has 1+ bilateral lower extremity nonpitting edema. Diagnostic paracentesis is performed. Laboratory studies show: Hemoglobin 10 g/dL Leukocyte count 14,000/mm3 Platelet count 152,000/mm3 Serum Total protein 5.8 g/dL Albumin 3.5 g/dL AST 18 U/L ALT 19 U/L Total bilirubin 0.8 mg/dL HbA1c 8.1% Peritoneal fluid analysis Color Cloudy Cell count 550/mm3 with lymphocytic predominance Total protein 3.5 g/dL Albumin 2.6 g/dL Glucose 60 mg/dL Triglycerides 360 mg/dL Peritoneal fluid Gram stain is negative. Culture and cytology results are pending. Which of the following is the most likely cause of this patient's symptoms?