A 52-year-old Caucasian man presents to the clinic for evaluation of a mole on his back that he finds concerning. He states that his wife noticed the lesion and believes that it has been getting larger. On inspection, the lesion is 10 mm in diameter with irregular borders. A biopsy is performed. Pathology reveals abnormal melanocytes forming nests at the dermo-epidermal junction and discohesive cell growth into the epidermis. What is the most likely diagnosis?
ADesmoplastic melanoma
BLentigo maligna melanoma
CSuperficial spreading melanoma
DNodular melanoma
EAcral lentiginous melanoma
A 19-year-old man presents to his primary care physician for evaluation before going off to college. Specifically, he wants to know how to stay healthy while living outside his home. Since childhood he has suffered severe sunburns even when he goes outside for a small period of time. He has also developed many freckles and rough-surfaced growths starting at the same age. Finally, his eyes are very sensitive and become irritated, bloodshot, and painful after being outside. A defect in a protein with which of the following functions is most likely responsible for this patient's symptoms?
ADistinguishing methylated from unmethylated strands
BRecognition of chemically dimerized bases
CEndonucleolytic removal of bases from backbone
DRecognition of mismatched bases
ESister chromatid binding and recombination
A 53-year-old farmer presents to the clinic for evaluation of a pigmented lesion on his arm. He states that he first noticed the lesion last year, but he believes that it has been slowly growing in size. He otherwise does not have any complaints and is generally healthy. Which of the following findings on physical exam would suggest a malignant diagnosis?
ASymmetrical ovoid lesion
BFlat lesion with symmetric hyperpigmentation
CTenderness to palpation
DHyperpigmented lesion with smooth borders
EDifferent pigmentation throughout the lesion
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