A 29-year-old woman, gravida 1, para 0, at 33 weeks' gestation comes to her doctor for a routine visit. Her pregnancy has been uncomplicated. She has systemic lupus erythematosus and has had no flares during her pregnancy. She does not smoke cigarettes, drink alcohol, or use illicit drugs. Current medications include iron, vitamin supplements, and hydroxychloroquine. Her temperature is 37.2°C (98.9°F), pulse is 70/min, respirations are 17/min, and blood pressure is 134/70 mm Hg. She appears well. Physical examination shows no abnormalities. Ultrasound demonstrates fetal rhythmic breathing for > 30 seconds, amniotic fluid with deepest vertical pocket of 1 cm, one distinct fetal body movement over 30 minutes, and no episodes of extremity extension over 30 minutes. Nonstress test is reactive and reassuring. Which of the following is the next best step in management?
AAdminister corticosteroids and continue close monitoring
BPerform cesarean delivery
CDiscontinue hydroxychloroquine and continue close monitoring
DInduction of labor
EReassurance with expectant management
A 25-year-old G1P0 woman at an estimated gestational age of 9 weeks presents for her first prenatal visit following a positive home pregnancy test. She says she missed 2 periods but assumed it was due to stress at work. She has decided to continue with the pregnancy. Her past medical history is significant for migraine headaches, seizures, and asthma. She takes multiple medications for her condition. Physical examination is unremarkable. An ultrasound confirms a 9-week-old intrauterine pregnancy. Which of the following medications poses the greatest risk to the fetus?
AValproic acid
BBudesonide
CAcetaminophen
DSumatriptan
EAlbuterol
A 29-year-old woman comes to the office with her husband because she has had 4 spontaneous abortions. Regarding her medical history, she was diagnosed with systemic lupus erythematosus 9 years ago, had a stroke 3 years ago, and was diagnosed with deep vein thrombosis in the same year. She has no relevant family history. Her vital signs include: heart rate 78/min, respiratory rate 14/min, temperature 37.5°C (99.5°F), and blood pressure 120/85 mm Hg. The physical examination is unremarkable. The complete blood count results are as follows: Hemoglobin 12.9 g/dL Hematocrit 40% Leukocyte count 8,500/mm3 Neutrophils 55% Bands 2% Eosinophils 1% Basophils 0% Lymphocytes 29% Monocytes 2% Platelet count 422,000/mm3 Her coagulation test results are as follows: Partial thromboplastin time (activated) 50.9 s Prothrombin time 13.0 s A VDRL test is done, and the result is positive. Mixing studies are performed, and they fail to correct aPTT. What is the most likely cause in this patient?
AAntithrombin deficiency
BProtein S deficiency
CProtein C deficiency
DAntiphospholipid syndrome
EFactor V Leiden mutation
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