A 29-year-old man comes to the physician for a routine health maintenance examination. He feels well. He works as a nurse at a local hospital in the city. Three days ago, he had a needlestick injury from a patient whose serology is positive for hepatitis B. He completed the 3-dose regimen of the hepatitis B vaccine 2 years ago. His other immunizations are up-to-date. He appears healthy. Physical examination shows no abnormalities. He is concerned about his risk of being infected with hepatitis B following his needlestick injury. Serum studies show negative results for hepatitis B surface antigen, hepatitis B surface antibody, and hepatitis C antibody. Which of the following is the most appropriate next step in management?
ARevaccinate with 3-dose regimen of hepatitis B vaccine
BRevaccinate with two doses of hepatitis B vaccine
CAdminister hepatitis B immunoglobulin
DAdminister hepatitis B immunoglobulin and 3-dose regimen of hepatitis B vaccine
EAdminister hepatitis B immunoglobulin and single dose hepatitis B vaccine
A 57-year-old man comes to the physician for a follow-up visit. Serum studies show: AST 134 U/L ALT 152 U/L Hepatitis B surface antigen Positive A photomicrograph of the microscopic findings of a liver biopsy is shown. These biopsy findings are most characteristic of which of the following types of inflammatory reactions?
AMalignant transformation
BGranulomatous inflammation
CChronic inflammation
DAcute inflammation
EIschemic necrosis
Researchers are investigating oncogenes, specifically the KRAS gene that is associated with colon, lung, and pancreatic cancer. They have established that the gain-of-function mutation in this gene increases the chance of cancer development. They are also working to advance the research further to study tumor suppressor genes. Which of the genes below is considered a tumor suppressor gene?
AHer2/neu
BBRAF
CBCL-2
DJAK2
ERb
+ 7 more in the PDF
Browse all chapters