A previously healthy 61-year-old man comes to the physician because of bilateral knee pain for the past year. The pain is worse with movement and is relieved with rest. Physical examination shows crepitus, pain, and decreased range of motion with complete flexion and extension of both knees. There is no warmth, redness, or swelling. X-rays of both knees show irregular joint space narrowing, osteophytes, and subchondral cysts. Which of the following is the most appropriate pharmacotherapy?
AAllopurinol
BNaproxen
CCelecoxib
DInfliximab
EPrednisone
A 58-year-old woman comes to the physician because of a 2-year history of progressively worsening pain in her knees and fingers. The knee pain is worse when she walks for longer than 30 minutes. When she wakes up in the morning, her fingers and knees are stiff for about 15 minutes. She cannot recall any trauma to the joints. She was treated with amoxicillin following a tick bite 2 years ago. She is otherwise healthy and only takes a multivitamin and occasionally acetaminophen for the pain. She drinks 1–2 glasses of wine daily. She is 160 cm (5 ft 3 in) tall and weighs 79 kg (174 lb); BMI is 31 kg/m2. Her temperature is 36.9°C (98.4°F), pulse is 70/min, and blood pressure is 133/78 mm Hg. Examination of the lower extremities reveals mild genu varum. Range of motion of both knees is limited; there is palpable crepitus. Complete flexion and extension elicit pain. Tender nodules are present on the proximal and distal interphalangeal joints of the index, ring, and little fingers bilaterally. Which of the following is the most likely diagnosis?
ASeptic arthritis
BLyme arthritis
CGout
DPseudogout
EOsteoarthritis
A 57-year-old woman presents to her primary care physician with a concern for joint pain. She states that she often feels minor joint pain and morning stiffness in both of her hands every day, particularly in the joints of her fingers. Her symptoms tend to improve as the day goes on and she states they are not impacting the quality of her life. She lives alone as her partner recently died. She smokes 1 pack of cigarettes per day and drinks 2-3 alcoholic drinks per day. Her last menses was at age 45 and she works at a library. The patient has a history of diabetes and chronic kidney disease with her last GFR at 45 mL/min. Her temperature is 97.5°F (36.4°C), blood pressure is 117/58 mmHg, pulse is 90/min, respirations are 14/min, and oxygen saturation is 98% on room air. Physical examination is within normal limits. Which of the following interventions is appropriate management of future complications in this patient?
AMethotrexate
BIbuprofen
CPrednisone
DAlendronate
EInfliximab
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