A 53-year-old woman presents to the emergency room with severe chest pain radiating to the back. She was diagnosed with acute aortic dissection. A few hours into the resuscitation, she was having oliguria. Laboratory findings show a serum creatinine level of 5.3 mg/dL. Which of the following casts are most likely to be seen on urinalysis?
ARBC casts
BFatty casts
CMuddy brown casts
DWaxy casts
EHyaline casts
A 32-year-old man is brought to the emergency department after a car accident; he was extricated after 4 hours. He did not lose consciousness and does not have headache or nausea. He is in severe pain. He sustained severe injuries to both arms and the trauma team determines that surgical intervention is needed. Urinary catheterization shows dark colored urine. His temperature is 38°C (100.4°F), pulse is 110/min, and blood pressure is 90/60 mm Hg. The patient is alert and oriented. Examination shows multiple injuries to the upper extremities, contusions on the trunk, and abdominal tenderness. Laboratory studies show: Hemoglobin 9.2 g/dL Leukocyte count 10,900/mm3 Platelet count 310,000/mm3 Serum Na+ 137 mEq/L K+ 6.8 mEq/L Cl- 97 mEq/L Glucose 168 mg/dL Creatinine 1.7 mg/dL Calcium 7.7 mg/dL Arterial blood gas analysis on room air shows a pH of 7.30 and a serum bicarbonate of 14 mEq/L. An ECG shows peaked T waves. A FAST scan of the abdomen is negative. Two large bore cannulas are inserted and intravenous fluids are administered. Which of the following is the most appropriate next step in management?
AIntravenous mannitol
BIntravenous sodium bicarbonate
CPacked red blood cell transfusion
DIntravenous calcium gluconate
EIntravenous insulin
A 52-year-old man is brought to the emergency department by ambulance after a motor vehicle accident. He was an unrestrained passenger who was ejected from the vehicle. On presentation, he is found to be actively bleeding from numerous wounds. His blood pressure is 76/42 mmHg and pulse is 152/min. Attempts at resuscitation fail, and he dies 25 minutes later. Autopsy shows blood in the peritoneal cavity, and histology of the kidney reveals swelling of the proximal convoluted tubule epithelial cells. Which of the following is most likely the mechanism underlying the renal cell findings?
ADecreased activity of caspase 7
BIncreased activity of caspase 9
CIncreased function of the Na+/K+-ATPase
DIncreased activity of caspase 8
EDecreased function of the Na+/K+-ATPase
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