Coagulation factor disordersDownloads

A 14-year-old boy presents with his mother complaining of a swollen, red, painful left knee. His physician aspirates the joint and discovers frank blood. The patient denies a recent history of trauma to the knee. Upon further discussion, the mother describes that her son has had multiple swollen painful joints before, often without evidence of trauma. She also mentions a history of frequent nosebleeds and gum bleeding following visits to the dentist. Which of the following is the most likely underlying diagnosis?

An otherwise healthy 23-year-old man comes to the physician because of a 3-day history of mild persistent bleeding from the site of a tooth extraction. He has no prior history of medical procedures or surgeries and no history of easy bruising. He appears well. Vital signs are within normal limits. Laboratory studies show: Hemoglobin 12.4 g/dL Platelets 200,000/mm3 Serum Prothrombin time 25 seconds Partial thromboplastin time (activated) 35 seconds Deficiency of which of the following coagulation factors is the most likely cause of this patient’s condition?