Chapter·Internal MedicineEndocrinology (diabetes, thyroid disorders)

HypothyroidismDownloads

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1

A 43-year-old woman presents to the physician with the complaint of worsening fatigue over the past several months. She has found that she requires nearly double the amount of coffee consumption each day to stay awake at work and that despite maintaining a balanced, healthy diet, she has experienced significant weight gain. A blood test confirms the presence of anti-thyroid peroxidase antibodies. Which of the following additional findings would be most consistent with the underlying pathophysiology of her condition?

AGalactorrhea

BConstipation

CBrisk deep tendon reflexes

DDiarrhea

EHeat intolerance

2

A 45-year-old woman presents to her primary care provider complaining of daytime drowsiness and fatigue. She reports that she can manage at most a couple of hours of work before needing a nap. She has also noted impaired memory and a 6.8 kg (15 lb) weight gain. She denies shortness of breath, chest pain, lightheadedness, or blood in her stool. At the doctor’s office, the vital signs include: pulse 58/min, blood pressure 104/68 mm Hg, and oxygen saturation 99% on room air. The physical exam is notable only for slightly dry skin. The complete blood count (CBC) is within normal limits. Which of the following is a likely additional finding in this patient?

ATremor

BAnxiety

CHypercholesterolemia

DLid lag

EPalpitations

3

A 27-year-old G1P0 at 12 weeks estimated gestational age presents for prenatal care. The patient says she has occasional nausea and vomiting and a few episodes of palpitations and diarrhea this last week. Physical examination is unremarkable, except for a heart rate of 145/min. Basic thyroid function tests are shown in the table below. Which of the following additional laboratory tests would be most useful in assessing this patient's condition? Thyroid-stimulating hormone (TSH) 0.28 mIU/L (0.3–4.5 mIU/L) Total T4 12 µg/dL (5.4–11.5 µg/dL)

AThyrotropin receptor antibodies (TRAb)

BTotal triiodothyronine (T3) levels

CThyroid peroxidase (TPO) antibodies

DFree thyroxine (T4) levels

EThyroxine-binding globulin (TBG) levels

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