A 32-year-old woman is brought to your office by her husband. The husband says that she had been acting strange lately. She has been forgetful, and she sometimes becomes angered for no reason, which is highly unusual for her. She has also been having random, uncontrollable movements, which are also new. On examination, she appears withdrawn and flat. On further questioning, she reveals that her father died at age 45 from a movement disorder. Which of the following is the pathological hallmark of the patient's condition?
ALipohyalinosis
BLoss of neurons in the caudate nucleus and putamen
CSubstantia nigra pars compacta
DAlpha-synuclein intracellular inclusions
EBeta-amyloid plaques
Which factor most strongly influences protein filtration at the glomerulus?
AElectrical charge
BMolecular size
CShape
DTemperature
An investigator studying epigenetic mechanisms isolates histone proteins, the structural motifs involved in DNA binding and regulation of transcription. The peptide bonds of histone proteins are hydrolyzed and one type of amino acid is isolated. At normal body pH, this amino acid has a net charge of +1 . The investigator performs titration of this amino acid and obtains the graph shown. The isolated amino acid is most likely which of the following?
AProline
BLysine
CAspartate
DSerine
EHistidine
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