Chapter·BiochemistryTranscription/translation

Post-transcriptional modificationsDownloads

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Sample Questions

1

An investigator is developing a drug for muscle spasms. The drug inactivates muscular contraction by blocking the site where calcium ions bind to regulate actin-myosin interaction. Which of the following is the most likely site of action of this drug?

ATroponin C

BMyosin-binding site

CAcetylcholine receptor

DRyanodine receptor

EMyosin head

2

A 25-year-old female comes to the clinic complaining of fatigue and palpitations. She has been undergoing immense stress from her thesis defense and has been extremely tired. The patient denies any weight loss, diarrhea, cold/heat intolerance. TSH was within normal limits. She reports a family history of "blood disease" and was later confirmed positive for β-thalassemia minor. It is believed that abnormal splicing of the beta globin gene results in β-thalassemia. What is removed during this process that allows RNA to be significantly shorter than DNA?

A3'-poly(A) tail

BExons

CIntrons

DmicroRNAs

EsnRNPs

3

An investigator studying protein synthesis in human stem cells isolates tRNA molecules bound to mRNA molecules. The isolated tRNA molecules have inosine in the 5' position of the anticodon; of these, some are bound to adenine, some to cytosine, and some to uracil at the 3' position of the mRNA codon. Which of the following properties of the genetic code is best illustrated by this finding?

AUnambiguity

BNon-overlapping

CDegeneracy

DSpecificity of the start codon

ESpecificity of stop codons

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