Chapter·BiochemistryGlycolysis

Overview and regulation of glycolysisDownloads

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1

A 45-year-old man is brought to the emergency department by ambulance after vomiting blood. The patient reports that he only ate a small snack the morning before and had not eaten anything for over 24 hours. At the hospital, the patient is stabilized. He is admitted to a surgical floor and placed on NPO with a nasogastric tube set to intermittent suction. He has been previously diagnosed with liver cirrhosis. An esophagogastroduodenoscopy (EGD) has been planned for the next afternoon. At the time of endoscopy, some pathways were generating glucose to maintain serum glucose levels. Which of the following enzymes catalyzes the irreversible biochemical reaction of this process?

AGlucose-6-phosphate dehydrogenase

BGlycogen phosphorylase

CEnolase

DGlyceraldehyde-3-phosphate dehydrogenase

EFructose-1,6-bisphosphatase

2

A 16-year-old boy presents with acute left-sided weakness. The patient is obtunded and can not provide any history other than his stomach hurts. The patient’s friend states that the patient has had episodes like this in the past and that “he has the same weird disease as his mom”. On physical examination, strength is 1 out of 5 in the left upper and lower extremities. A noncontrast CT scan of the head is normal. Laboratory tests reveal an anion gap metabolic acidosis. Which of the following is a normal function of the structure causing this patient’s condition?

ARegulation of blood glucose

BSynthesis of fatty acids

CProduction of bile acids

DMetabolism of purines

EConversion of ammonia to urea

3

A 25-year-old man is brought to the emergency department 6 hours after rescuing babies and puppies from a burning daycare center. He says that he has a severe headache, feels nauseous and dizzy. He is tachypneic. An arterial blood gas shows pH 7.3, PaCO2 49 mmHg, PaO2 80 mmHg. Serum lactate level is 6 mmol/L. What biochemical process explains these laboratory values?

AIncreased oxidation of NADH

BLow lactate dehydrogenase activity

CLow pyruvate dehydrogenase activity

DHigh pyruvate dehydrogenase activity

EIncreased decarboxylation of pyruvate

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