A researcher is tracing the fate of C-peptide, a product of preproinsulin cleavage. Which of the following is a true statement regarding the fate of C-peptide?
AC-peptide exits the cells via a protein channel
BC-peptide is further cleaved into insulin
CC-peptide is packaged with insulin in secretory vesicles
DC-peptide is immediately degraded by the proteasome
EC-peptide activates an intracellular signaling cascade
A 52-year-old woman presents to the urgent care center with several hours of worsening abdominal discomfort with radiation to the back. The patient also complains of malaise, chills, nausea, and vomiting. Social history is notable for alcoholism. On physical exam, she is febrile to 39.5°C (103.1°F), and she is diffusely tender to abdominal palpation. Complete blood count is notable for 13,500 white blood cells, bilirubin 2.1, lipase 842, and amylase 3,210. Given the following options, what is the most likely diagnosis?
ACholedocholithiasis
BAscending cholangitis
CGallstone pancreatitis
DCholelithiasis
EAcute cholecystitis
A 46-year-old woman presents to her primary care physician with complaints of increasing left upper quadrant discomfort. She has a known history of type 1 Gaucher disease. On physical examination, her spleen is palpable 8 cm below the costal margin. Routine laboratory work reveals severe pancytopenia. After consultation with the patient on the risks of her condition, the patient decides to undergo a splenectomy. Which of the following is more likely to occur as a consequence of splenectomy in this patient?
AThrombocytopenia
BLeukopenia
CPneumococcal septicemia
DStaphylococcal septicemia
EAnemia
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