A 78-year-old man dies suddenly from complications of acute kidney failure. An autopsy is performed and microscopic evaluation of the kidneys shows pale, swollen cells in the proximal convoluted tubules. Microscopic evaluation of the liver shows similar findings. Which of the following is the most likely underlying mechanism of these findings?
ADouble-stranded DNA breakage
BImpaired Na+/K+-ATPase pump activity
CFree radical formation
DCytochrome C release
ECytoplasmic triglyceride accumulation
A previously healthy 82-year-old man dies in a motor vehicle collision. At autopsy, the heart shows slight ventricular thickening. There are abnormal, insoluble aggregations of protein filaments in beta-pleated linear sheets in the ventricular walls and, to a lesser degree, in the atria and lungs. No other organs show this abnormality. Bone marrow examination shows no plasma cell dyscrasia. The abnormal protein aggregations are most likely composed of which of the following?
AImmunoglobulin light chain
BNormal transthyretin
Cβ-amyloid peptide
DNatriuretic peptide
ESerum amyloid A
A 74-year-old man presents with complaints of sudden severe crushing retrosternal pain. The pain radiated to his left arm shortly after it began, and he was subsequently rushed to the emergency department for evaluation. His troponins and creatine kinase-MB (CK-MB) were elevated. Unfortunately, the patient died within the next 2 hours and an autopsy was performed immediately. The gross examination of the heart will show?
AWhite, patchy, non-contractile scar
BNormal heart tissue
CPallor of the infarcted tissue
DAbundant neutrophils
ERed granulation tissue surrounding the infarction
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