Chapter·PhysiologyAcid-base balance

Respiratory acidosis mechanisms and compensationDownloads

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1

A 60-year-old woman is brought to the emergency department by her husband because of worsening shortness of breath over the past 2 days. Last week, she had a sore throat and a low-grade fever. She has coughed up white sputum each morning for the past 2 years. She has hypertension and type 2 diabetes mellitus. She has smoked 2 packs of cigarettes daily for 35 years. Current medications include metformin and lisinopril. On examination, she occasionally has to catch her breath between sentences. Her temperature is 38.1°C (100.6°F), pulse is 85/min, respirations are 16/min, and blood pressure is 140/70 mm Hg. Expiratory wheezes with a prolonged expiratory phase are heard over both lung fields. Arterial blood gas analysis on room air shows: pH 7.33 PCO2 53 mm Hg PO2 68 mm Hg An x-ray of the chest shows hyperinflation of bilateral lung fields and flattening of the diaphragm. Which of the following additional findings is most likely in this patient?

ADecreased urinary bicarbonate excretion

BDecreased urinary chloride concentration

CIncreased serum anion gap

DIncreased urine osmolar gap

EIncreased urinary pH

2

A 58-year-old man presents to the emergency department with a chief complaint of ringing in his ears that started several hours previously that has progressed to confusion. The patient denies any history of medical problems except for bilateral knee arthritis. He was recently seen by an orthopedic surgeon to evaluate his bilateral knee arthritis but has opted to not undergo knee replacement and prefers medical management. His wife noted that prior to them going on a hike today, he seemed confused and not himself. They decided to stay home, and roughly 14 hours later, he was no longer making any sense. Physical exam is notable for a confused man. The patient's vitals are being performed and his labs are being drawn. Which of the following is most likely to be seen on blood gas analysis?

ApH: 7.30, PaCO2: 15 mmHg, HCO3-: 16 mEq/L

BpH: 7.37, PaCO2: 41 mmHg, HCO3-: 12 mEq/L

CpH: 7.41, PaCO2: 65 mmHg, HCO3-: 34 mEq/L

DpH: 7.47, PaCO2: 11 mmHg, HCO3-: 24 mEq/L

EpH: 7.31, PaCO2: 31 mmHg, HCO3-: 15 mEq/L

3

A 72-year-old female is brought to the emergency department after being found unresponsive in her garage with an open bottle of unmarked fluid. She is confused and is unable to answer questions on arrival. Her medical history is significant for Alzheimer disease, but her family says she has no medical comorbidities. Serum analysis of this patient's blood shows a pH of 7.28 with a high anion gap. The electrolyte that is most likely significantly decreased in this patient follows which of the following concentration curves across the proximal tubule of the kidney?

ACurve C

BCurve E

CCurve B

DCurve A

ECurve D

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