You are taking care of a patient with renal failure secondary to anti-fungal therapy. The patient is a 66-year-old male being treated for cryptococcal meningitis. This drug has a variety of known side effects including acute febrile reactions to infusions, anemia, hypokalemia and hypomagnesemia. What is the mechanism of action of this drug?
AInhibition of squalene epoxidase
BBinding of the 50S subunit
CPore formation secondary to ergosterol binding
DDisruption of microtubule formation
EInhibition of 1,3-beta-glucan synthase
A 57-year-old florist presents to his family physician with nodular lesions on his right hand and forearm. He explains that he got pricked by a rose thorn on his right "pointer finger" where the first lesions appeared, and the other lesions then began to appear in an ascending manner. The physician prescribed a medication and warned him of gynecomastia as a side effect if taken for long periods of time. Which of the following is the mechanism of action of the medication?
AInhibits squalene epoxidase
BBinds to ergosterol, forming destructive pores in cell membrane
CDisrupts microtubule function
DInhibits ergosterol synthesis
EInhibits formation of beta glucan
A 26-year-old female with AIDS (CD4 count: 47) presents to the emergency department in severe pain. She states that over the past week she has been fatigued and has had a progressively worse headache and fever. These symptoms have failed to remit leading her to seek care in the ED. A lumbar puncture is performed which demonstrates an opening pressure of 285 mm H2O, increased lymphocytes, elevated protein, and decreased glucose. The emergency physician subsequently initiates treatment with IV amphotericin B and PO flucytosine. What additional treatment in the acute setting may be warranted in this patient?
ASerial lumbar punctures
BFluconazole
CMannitol
DChloramphenicol
EAcetazolamide
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