Chapter·PharmacologyAnti-neoplastic drugs

Monoclonal antibodies in cancerDownloads

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Sample Questions

1

A 33-year-old woman with a history of multiple sclerosis is brought to the physician because of dizziness, urinary incontinence, loss of vision in her right eye, and numbness and weakness of the left leg. She has had recurrent episodes of neurological symptoms despite several changes in her medication regimen. An MRI of the brain shows several new enhancing lesions in the periventricular white matter and the brainstem. Treatment with a drug that binds to CD52 is initiated. Which of the following agents was most likely prescribed?

AAlemtuzumab

BEculizumab

CAbciximab

DRituximab

EBevacizumab

2

A 40-year-old male with a history of chronic alcoholism recently received a liver transplant. Two weeks following the transplant, the patient presents with a skin rash and frequent episodes of bloody diarrhea. A colonoscopy is performed and biopsy reveals apoptosis of colonic epithelial cells. What is most likely mediating these symptoms?

ADonor T-cells

BRecipient T-cells

CRecipient B-cells

DRecipient antibodies

EDonor B-cells

3

A 55-year-old Caucasian male presents for a routine colonoscopy. A polyp is found in the patient's transverse colon and is found to be cancerous on histological evaluation. Upon examination, it is found that these cancerous cells have decreased MHC class I expression on their surface. Which immune system cell is most capable of killing these tumor cells?

ACytotoxic T-cells

BB-cells

CMacrophages

DNatural killer cells

EEosinophils

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